GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs994533 | 1 | rs4674169 | chr2:218276240 | DIRC3 | chr2:218148748-218621316:- | -0.21 | -4.95 | 1.04E-6 | Height |
| THCA | cis | rs3820928 | 1 | rs4675115 | chr2:227769123 | COL4A4 | chr2:227867435-228029275:- | 0.15 | 3.56 | 0.000413 | Pulmonary function |
| THCA | cis | rs3820928 | 1 | rs4675116 | chr2:227769607 | COL4A4 | chr2:227867435-228029275:- | 0.16 | 3.87 | 0.000122 | Pulmonary function |
| THCA | cis | rs3820928 | 1 | rs4675119 | chr2:227774635 | COL4A4 | chr2:227867435-228029275:- | 0.14 | 3.56 | 0.000415 | Pulmonary function |
| THCA | cis | rs3820928 | 1 | rs4675120 | chr2:227774888 | COL4A4 | chr2:227867435-228029275:- | 0.15 | 3.79 | 0.00017 | Pulmonary function |
| THCA | cis | rs7582720 | 1 | rs4675310 | chr2:203880834 | ALS2CR8 | chr2:203776978-203851060:+ | 0.27 | 5.29 | 1.89E-7 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7582720 | 1 | rs4675310 | chr2:203880834 | ICA1L | chr2:203637873-203736371:- | -0.26 | -4.31 | 2.0E-5 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs3771570 | 1 | rs4675811 | chr2:242402062 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -5.3 | 1.81E-7 | Prostate cancer |
| THCA | cis | rs6748734 | 1 | rs4675860 | chr2:241840417 | C2orf54 | chr2:241825466-241835573:- | 0.29 | 6.22 | 1.06E-9 | Urinary metabolites |
| THCA | cis | rs6748734 | 1 | rs4675863 | chr2:241830763 | C2orf54 | chr2:241825466-241835573:- | 0.29 | 6.38 | 4.11E-10 | Urinary metabolites |
| THCA | cis | rs6748734 | 1 | rs4675868 | chr2:241828542 | C2orf54 | chr2:241825466-241835573:- | 0.29 | 6.38 | 4.11E-10 | Urinary metabolites |
| THCA | cis | rs6748734 | 1 | rs4675874 | chr2:241819796 | C2orf54 | chr2:241825466-241835573:- | -0.3 | -6.4 | 3.61E-10 | Urinary metabolites |
| THCA | cis | rs7611238 | 1 | rs4677834 | chr3:195093631 | C3orf21 | chr3:194789015-194991895:- | -0.28 | -6.48 | 2.28E-10 | Body mass index |
| THCA | cis | rs4678181 | 1 | rs4678176 | chr3:122009175 | PARP15 | chr3:122296449-122355536:+ | 0.22 | 3.51 | 0.000498 | Calcium levels |
| THCA | cis | rs4680 | 1 | rs4680 | chr22:19951271 | DGCR9 | chr22:19005347-19007760:+ | -0.16 | -3.42 | 0.000677 | Blood metabolite levels |